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Description:Using advanced methods to measure FDG uptake, Dr. This receptor helps cells take in glucose, the sugar they use to fuel their overactive inflammatory response. In the second image, the spike in sugar-hungry cells corresponds to a diagnosis of immune reconstitution syndrome, or IRIS. The researchers also noted that the pre-treatment PET scans unexpectedly detected "hot spots" of viral activity in the spleen and bone marrow -- areas not usually known to harbor significant reservoirs of HIV or immune responses to the virus. Sereti and her team could track the inflammatory response of IRIS by looking at patient's blood samples, they wondered if they could also visualize this disease process in action with PET.